Obesity is associated, in both sexes, with the alteration of reproductive hormones (the cause of infertility).
In humans there is a gradual decrease in the levels of androgens (particularly testosterone), up to a possible hypogonadotropic hypogonadism, resulting in fertility impairment. It also has a
hyperestrogenism on low clinical importance, due to the increase of aromatase activity of adipose tissue (converts androgens into estrogens). The woman with
obestià android has a high incidence of menstrual disorders (oligomenorrhea, amenorrhea) and hirsutism, to impaired fertility. The endocrine profile of women with obesity gynoid is different.
The hormonal function is characterized by hyperandrogenism, hyperestrogenism functional alteration of the hypothalamic-pituitary-ovarian.
These alterations are associated with hyperinsulinemia and insulin resistance, which leads to polycystic ovary syndrome.
Therapies to reduce insulin levels, or capable of sensitizing tissues to insulin show an improvement of hyperandrogenism and hirsutism. Returns to the menstrual cycle and ovulation.
0 comments:
Post a Comment